Research & Innovation

Research at SLC

Sheba Longevity encompasses utilizing data science and AI techniques to analyze complex datasets, conduct clinical trials to evaluate longevity therapeutics, study biomarkers of healthy longevity, explore fundamental biological mechanisms, and translate laboratory findings into practical healthcare applications.

Currently Recruiting

The SHARP study - Sheba Healthspan Research Population trial

We are currently conducting a randomized control study among healthy adults to assess the effect of a personalized health and behavior intervention program based on a multi model analysis system and diagnostic of multidimensional performance domains.

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Research Fields

Data science & AI

Clinical trials

Basic Science

Translational Research

Ongoing Research

Biological age, mortality and hospitalization rate

Leading PI: Dr. Abigail Goshen, Prof Tzipi Strauss

Melatonin and circadian rhythms in aging & hypertension

Leading PI: Dr. Avshalom Leibowitz

Environmental exposures affecting menopausal timing and symptoms

Leading PI: Dr.Lauren Petrick

Validating an Israeli Frailty Index score

Leading PI: Dr. Abigail Goshen, Prof Tzipi Strauss

Voice recognition and CV risk

Leading PI: Dr. Elad Maor

Developing predictive models based on metabolite profiles to identify individuals at high risk of developing CVD

Leading PI: Dr. Michael Elgart and Dr. Abigail Goshen

The Gut Microbiome and Cognitive Performance longitudinal study

Leading PI: Prof. Tzipi Strauss , Prof. Eran Elinav, Dr Abigail Goshen

Utilizing DELPHI test results for Early Detection and Predictive ability of mild cognitive decline and physical frailty

Leading PI: Dr. Abigail Goshen

Publications

Association of Diet Quality With Longevity and Successful Aging in Israeli Adults 65 Years or Older

JAMA Network Open

June 1, 2022

Association of Diet Quality With Longevity and Successful Aging in Israeli Adults 65 Years or Older

Abigail Goshen, MSc; Uri Goldbourt, PhD; Yael Benyamini, PhD; Tal Shimony, MSc; Lital Keinan-Boker, MD, PhD; Yariv Gerber, PhD

Diet Quality and Incident Frailty in Adults 65 Years or Older: The Israeli Longitudinal Study on Aging - ScienceDirect.

Mayo Clinic Proceedings

December 1, 2023

Diet Quality and Incident Frailty in Adults 65 Years or Older: The Israeli Longitudinal Study on Aging - ScienceDirect

Abigail Goshen PhD, Uri Goldbourt PhD, Yael Benyamini PhD, Tal Shimony MSc, Lital Keinan-Boker MD, PhD, Yariv Gerber PhD

Advanced Pathological Ageing Should be Represented in the ICD

The Lancet

January 1, 2022

Advanced Pathological Ageing Should be Represented in the ICD

Evelyne Bischof, Andrea B Maier, Kai-Fu Lee, Alex Zhavoronkov, *David Sinclair

Artifcial intelligence in longevity medicine

Nature Aging

January 1, 2021

Artifcial Intelligence in Longevity Medicine

Alex Zhavoronkov, Evelyne Bischof and Kai-Fu Lee

Longevity medicine: upskilling the physicians of tomorrow

The Lancet

March 12, 2021

Longevity Medicine: Upskilling the Physicians of Tomorrow

Evelyne Bischof, Morten Scheibye-Knudsen*, Richard Siow, Alexey Moskalev

Establishing healthy longevity clinics in publicly funded hospitals

GeroScience

March 21, 2024

Establishing healthy longevity clinics in publicly funded hospitals

Tzipora Strauss , Sara L. R. Bonnes, Allyson K. Palmer, Ryan T. Hurt, Louis Island, Abigail Goshen, Laureen Y. T. Wang, James L. Kirkland, Evelyne Bischof & Andrea B. Maier